Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

Keyphrases

• COL1A2 100%
• Smad3 100%
• Glomerulosclerosis 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• Transforming Growth Factor-β 33%
• Hypoxia Responsive Element 25%
• Growth Factor Signaling 16%
• Smad 8%
• Collagen Expression 8%
• Kidney 8%
• Type I Collagen 8%
• Collagen Accumulation 8%
• Podocyte 8%
• Chronic Kidney Disease 8%
• Renal Cell 8%
• Activation Domain 8%
• Lysate 8%
• Transcriptional Analysis 8%
• DNA Binding 8%
• Hypoxia 8%
• Null Mice 8%
• Disease Model 8%
• Mouse Embryonic Fibroblasts 8%
• Transcriptional Complex 8%
• Novel Interactions 8%
• Transcription Start Site 8%
• Ablation Model 8%

Biochemistry, Genetics and Molecular Biology

• COL1A2 100%
• Hypoxia Inducible Factor 1 100%
• Cancer Growth Factor 33%
• Promoter Region 25%
• Growth Factor Signaling 16%
• N-Terminus 8%
• Cell Lysate 8%
• Type I Collagen 8%
• Transactivation 8%
• Transcription 8%
• Podocyte 8%
• Knockout Mouse 8%
• DNA Binding 8%
• Transcription Initiation Site 8%
• Fibroblast 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Hypoxia Inducible Factor 1 100%
• Glomerulosclerosis 100%
• Hypoxia 33%
• Cancer Growth Factor 33%
• Knockout Mouse 8%
• Chronic Kidney Failure 8%
• Collagen Type 1 8%
• Disease Model 8%