TY - JOUR
T1 - IBD and the Gut Microbiota—from Bench to Personalized Medicine
AU - Bellaguarda, Emanuelle
AU - Chang, Eugene B.
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/4
Y1 - 2015/4
N2 - Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders involving the gastrointestinal (GI) tract, which arise from the confluence of genetic, immunological, microbial, and environmental factors. Clinical, genetic, and experimental data support the role of gut microbiota in contributing to the etiopathogenesis of these diseases. In IBD, the development of gut dysbiosis and imbalances in host–microbe relationships contribute to the extent, severity, and chronicity of intestinal inflammation. With continued advances in knowledge, technology, bioinformatics tools, and capabilities to define disease subsets, we will be able to lower risk and improve clinical outcomes in IBD through individualized interventions that restore host–microbial balance. This article provides a critical review of the field, based on the latest clinical and experimental information.
AB - Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders involving the gastrointestinal (GI) tract, which arise from the confluence of genetic, immunological, microbial, and environmental factors. Clinical, genetic, and experimental data support the role of gut microbiota in contributing to the etiopathogenesis of these diseases. In IBD, the development of gut dysbiosis and imbalances in host–microbe relationships contribute to the extent, severity, and chronicity of intestinal inflammation. With continued advances in knowledge, technology, bioinformatics tools, and capabilities to define disease subsets, we will be able to lower risk and improve clinical outcomes in IBD through individualized interventions that restore host–microbial balance. This article provides a critical review of the field, based on the latest clinical and experimental information.
KW - Antibiotics
KW - Crohn’s disease
KW - Dysbiosis
KW - Fecal microbiota transplantation
KW - Gut microbiome
KW - Host–microbe interactions
KW - IBD
KW - Intestinal inflammation
KW - Mucosal immunology
KW - Prebiotics
KW - Precision medicine
KW - Probiotics
KW - Ulcerative colitis
KW - Western diet
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U2 - 10.1007/s11894-015-0439-z
DO - 10.1007/s11894-015-0439-z
M3 - Review article
C2 - 25762474
AN - SCOPUS:84924787273
SN - 1522-8037
VL - 17
JO - Current gastroenterology reports
JF - Current gastroenterology reports
IS - 4
ER -