Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking

Keyphrases

• CFTR mutations 100%
• Cystic Fibrosis Transmembrane Conductance Regulator 100%
• CFTR Correctors 100%
• Small Interfering RNA (siRNA) 66%
• Action Targets 66%
• Small Molecules 33%
• Cell-based 33%
• Delocalization 33%
• Pharmacological Inhibitors 33%
• Electrophysiological Study 33%
• Specific Genes 33%
• Combination Therapy 33%
• In Vivo Mice 33%
• Knock 33%
• Cyclooxygenase-1 (COX-1) 33%
• Clinical History 33%
• VX-809 33%
• Current Response 33%
• Short-circuit Current 33%
• CF-1 Mouse 33%
• Mouse Assay 33%
• HBE Cells 33%
• COX-1 Inhibition 33%
• HTS Assay 33%
• CFTR Rescue 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Ibuprofen 100%
• Cystic Fibrosis Transmembrane Conductance Regulator 100%
• Lumacaftor 16%
• Small Interfering RNA 16%
• Prostaglandin Synthase 16%
• Combination Therapy 16%

Immunology and Microbiology

• Cystic Fibrosis Transmembrane Conductance Regulator 100%
• Short Circuit Current 100%