Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha

Ming Zhao*, Monday M. Onakpa, Bernard D. Santarsiero, Xiao Jun Huang, Xiao Qi Zhang, Jia Chen, Jian Jun Cheng, Richard Longnecker, Chun Tao Che

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The 17-norpimarane diterpene is a small group of natural products. A new member, icacinlactone H (1), and a new rearranged 17-norpimarane with an unprecedented carbon skeleton, icacintrichantholide (2), were isolated from Icacina trichantha. Their structures including the absolute configuration were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism analysis. A plausible biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant activity against herpes simplex viruses HSV-1 and HSV-2 as well as the Epstein-Barr virus at 50 μM.

Original languageEnglish (US)
Pages (from-to)3834-3837
Number of pages4
JournalOrganic Letters
Issue number15
StatePublished - Aug 7 2015

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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