ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis

Triet M. Bui, Hannah L. Wiesolek, Ronen Sumagin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory stimulation. Importantly, ICAM-1 serves as a biosensor to transduce outside-in-signaling via association of its cytoplasmic domain with the actin cytoskeleton following ligand engagement of the extracellular domain. Thus, ICAM-1 has emerged as a master regulator of many essential cellular functions both at the onset and at the resolution of pathologic conditions. Because the role of ICAM-1 in driving inflammatory responses is well recognized, this review will mainly focus on newly emerging roles of ICAM-1 in epithelial injury-resolution responses, as well as immune cell effector function in inflammation and tumorigenesis. ICAM-1 has been of clinical and therapeutic interest for some time now; however, several attempts at inhibiting its function to improve injury resolution have failed. Perhaps, better understanding of its beneficial roles in resolution of inflammation or its emerging function in tumorigenesis will spark new interest in revisiting the clinical value of ICAM-1 as a potential therapeutic target.

Original languageEnglish (US)
Pages (from-to)787-799
Number of pages13
JournalJournal of Leukocyte Biology
Volume108
Issue number3
DOIs
StatePublished - Sep 1 2020

Keywords

  • Inflammation
  • adhesion molecules
  • immune cells
  • metastasis
  • migration
  • tumorigenesis
  • wound healing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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