Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: A 2-year multicentre, comparative, prospective cohort study

Andreas Vychytil*, César Remón, Catherine Michel, Paul Williams, Ana Rodríguez-Carmona, Belén Marrón, Ed Vonesh, Synke Van Der Heyden, Jose C Divino Filho

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Background. Icodextrin is a glucose polymer derived by hydrolysis of cornstarch. The different biocompatibility profile of icodextrin-containing peritoneal dialysis (PD) solutions may have a positive influence on peritoneal host defence. Furthermore, cases of sterile peritonitis potentially associated with icodextrin have been reported. Methods. The primary objective of this multicentre, longitudinal, observational, non-interventional, prospective cohort study, which included 722 PD patients, was to evaluate the incidence of overall peritonitis in patients treated with icodextrin-containing PD solutions (Extraneal™) used during one long-dwell exchange/day compared with those treated with non-icodextrin-containing PD solutions. The secondary objective was to determine if culture-negative peritonitis rates differed between patients treated with icodextrin from two independent manufacturers. All peritonitis episodes were assessed by a Steering Committee in a blind manner. Results. There was no significant difference between icodextrin-treated and control patients in the adjusted overall, culture-positive or culture-negative peritonitis rates. When stratified by the icodextrin supplier, there was no significant difference in the adjusted rate of culture-negative peritonitis episodes between groups. Conclusion. Subjects receiving icodextrin as part of their PD regimen experienced neither a higher rate of culture-negative peritonitis nor a lower rate of infectious peritonitis compared with non-icodextrin users. There was no significant influence of the icodextrin raw material supplier on peritonitis rates.

Original languageEnglish (US)
Pages (from-to)3711-3719
Number of pages9
JournalNephrology Dialysis Transplantation
Volume23
Issue number11
DOIs
StatePublished - Nov 2008

Keywords

  • Biocompatibility
  • Glucose degradation products
  • Glucose polymer
  • Peptidoglycan
  • Sterile peritonitis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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    Vychytil, A., Remón, C., Michel, C., Williams, P., Rodríguez-Carmona, A., Marrón, B., Vonesh, E., Van Der Heyden, S., & Filho, J. C. D. (2008). Icodextrin does not impact infectious and culture-negative peritonitis rates in peritoneal dialysis patients: A 2-year multicentre, comparative, prospective cohort study. Nephrology Dialysis Transplantation, 23(11), 3711-3719. https://doi.org/10.1093/ndt/gfn322