Objective: To define seizure characteristics of Dravet syndrome (DS) with video-electroencephalographic (EEG) recording in different age groups. Methods: We reviewed 23 patients with 63 seizures in different age groups: group 1 (0-5. years old); group 2 (6-10. years old); and group 3 (11 or above). Results: We included 7, 11 and 5 patients in groups 1, 2, and 3 respectively. Younger children had seizures while awake = p = 0.005), provoked seizures = p = 0.05), focal seizure semiology = p = 0.02) and long seizure duration = p = 0.0004). Older children had seizures from sleep = p = 0.004), generalized seizure semiology = p = 0.01) and short seizure duration = p = 0.0007). A generalized ictal discharge was the most commonly observed EEG pattern (15/23, 65%), more frequently found in older children = p = 0.01). Ten patients (43%) had unclassified seizures or seizures with discordant EEG results. Postictal EEG suppression was found in 9 (39%). Conclusion: The phenotype of seizures and ictal EEG patterns in DS vary with age. Significance: These findings will enhance the recognition of DS in the adolescent population. The incidence of postictal EEG suppression seen in DS is significant because it is a possible biomarker for sudden unexpected death in epilepsy.
- Postictal generalized EEG suppression (PGES)
- Sudden unexpected death in epilepsy (SUDEP)
ASJC Scopus subject areas
- Sensory Systems
- Clinical Neurology
- Physiology (medical)