Abstract
The number of CD34+ cells infused influences the speed of hematologic recovery post-transplant. There are limited data on whether ideal (IBW) or actual (ABW) body weight should be used to calculate CD34+ cell dose. We compared the correlation between recovery to 0.5 × 109/l neutrophils and the CD34+ cell dose based upon ABW as well as IBW in 87 patients autografted for cancer. ABW was ≥25% over IBW in 43% of patients. The median number of CD34+ cells administered was 3.6 × 106/kg ABW and 4.2 × 106/kg IBW. The time to neutrophil recovery was 8-15 days (median 10). There was a stronger inverse correlation between CD34+ cell dose/IBW and neutrophil recovery (r2 = 0.308; P <0.0001) than between CD34+ cell dose/ABW and neutrophil recovery (r2 =0.267; P <0.0001). The median time to neutrophil recovery was comparable for those receiving ≥2 × 106/kg CD34+ cefls/kg IBW as well as ABW (10 days) and those receiving ≥2 × 106/kg CD34+ cells/kg IBW but <2/kg ABW (10 days), but was significantly slower for those receiving <2 × 106/kg CD34+ cells/kg IBW (12 days). These data show that the CD34+ cell dose based on IBW is a better predictor of neutrophil recovery after autotransplantation.
Original language | English (US) |
---|---|
Pages (from-to) | 861-864 |
Number of pages | 4 |
Journal | Bone Marrow Transplantation |
Volume | 31 |
Issue number | 10 |
DOIs | |
State | Published - 2003 |
Funding
This work was supported in part by the Auxiliary Board of the Northwestern Memorial Hospital.
Keywords
- Autotransplantation
- CD34+ cells
- Engraftment
- Myeloid recovery
- Weight
ASJC Scopus subject areas
- Hematology
- Transplantation