Ideal or actual body weight to calculate CD34+ cell doses for autologous hematopoietic stem cell transplantation?

M. Y. Ali, Y. Oyama, J. Monreal, J. N. Winter, M. S. Tallman, S. F. Williams, S. Singhal, L. I. Gordon, Jayesh Mehta

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The number of CD34+ cells infused influences the speed of hematologic recovery post-transplant. There are limited data on whether ideal (IBW) or actual (ABW) body weight should be used to calculate CD34+ cell dose. We compared the correlation between recovery to 0.5 × 109/l neutrophils and the CD34+ cell dose based upon ABW as well as IBW in 87 patients autografted for cancer. ABW was ≥25% over IBW in 43% of patients. The median number of CD34+ cells administered was 3.6 × 106/kg ABW and 4.2 × 106/kg IBW. The time to neutrophil recovery was 8-15 days (median 10). There was a stronger inverse correlation between CD34+ cell dose/IBW and neutrophil recovery (r2 = 0.308; P <0.0001) than between CD34+ cell dose/ABW and neutrophil recovery (r2 =0.267; P <0.0001). The median time to neutrophil recovery was comparable for those receiving ≥2 × 106/kg CD34+ cefls/kg IBW as well as ABW (10 days) and those receiving ≥2 × 106/kg CD34+ cells/kg IBW but <2/kg ABW (10 days), but was significantly slower for those receiving <2 × 106/kg CD34+ cells/kg IBW (12 days). These data show that the CD34+ cell dose based on IBW is a better predictor of neutrophil recovery after autotransplantation.

Original languageEnglish (US)
Pages (from-to)861-864
Number of pages4
JournalBone Marrow Transplantation
Volume31
Issue number10
DOIs
StatePublished - 2003

Keywords

  • Autotransplantation
  • CD34+ cells
  • Engraftment
  • Myeloid recovery
  • Weight

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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