Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25

C. Clayberger, A. M. Krensky, B. W. McIntyre, T. D. Koller, P. Parham, F. Brodsky, D. J. Linn, E. L. Evans

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

We describe the function and cell distribution of two novel cell surface antigens, L24 and L25. These antigens are broadly distributed on human lymphocytes. Monoclonal antibodies specific for these molecules block lysis by Class I- and II-specific cytotoxic T lymphocytes, but do not affect any other T cell functions tested. Anti-L24 antibody immunoprecipitates a molecule composed of two disulfide-linked monomers of 140 kd each. Anti-L25 antibody immunoprecipitates three proteins of 150, 85, and 75 kd. The study of these and other function associated molecules may provide insight into mechanisms of cytotoxic T lymphocyte recognition and/or function.

Original languageEnglish (US)
Pages (from-to)1510-1514
Number of pages5
JournalJournal of Immunology
Volume138
Issue number5
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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