Identification and genetic control of allotypic specificites on two variable region subgroups of rabbit immunoglobulin heavy chains

B. S. Kim, S. Dray*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

After absorption with selected individual rabbit sera, allo‐antibodies directed against the a‐negative IgG from homozygous a2‐suppressed rabbit resulted in the separation of three distinct antibody populations which are designated anti‐A31, anti‐x32 and anti‐y33. The mating studies indicated that the x32 and y33 allotypic specificities are not controlled by allelic alternatives. The inheritance of the x32 and y33 allotypes was found to be closely linked to that of the al, a2 or a3 allotypes. Five allogroups were identified: a1, x,y;a1,x,y33;a1,x32,y33;a2x32,y33; and a3,x32,y. As was found for the a1, a2 and a3 allotypic specificities, the x32 and y33 allotypic specificities are present on IgA and IgM as well as on IgG suggesting that the x32 and y33 allotypic specificities are located on the variable region of immunoglobulin heavy chains. Our results indicate that three closely linked VH genes code for the variable regions of rabbit Ig heavy chain subgroups.

Original languageEnglish (US)
Pages (from-to)509-514
Number of pages6
JournalEuropean Journal of Immunology
Volume2
Issue number6
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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