Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease

Roger W. Melvold*, Diane M. Jokinen, Stephen D. Miller, Mauro C. Dal Canto, Howard L. Lipton

*Corresponding author for this work

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Theiler's virus-induced demyelinating disease results from a chronic infection in the white matter of the central nervous system and provides an excellent model for human multiple sclerosis. Like multiple sclerosis, there are genetic risk factors in disease development, including genes associated with the major histocompatibility complex and with those encoding the β chain of the T-cell receptor. Comparisons of the susceptible DBA/2 and resistant C57BL/6 strains have indicated an important role for the H-2D locus and for a non-H-2 gene (not involving the β chain of the T-cell receptor) in differential susceptibility. In the present report, analysis of recombinant-inbred strains (BXD) between the DBA/2 and C57BL/6 strains indicated that this non-H-2 locus is located at the centromeric end of chromosome 3 near (4 ± 4 centimorgans) the carbonic anhydrase-2 (Car-2) enzyme locus.

Original languageEnglish (US)
Pages (from-to)686-690
Number of pages5
JournalJournal of virology
Volume64
Issue number2
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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