Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice

Robert L. Yauch, Kaye Kerekes, Keshma Saujani, Byung S. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Intracerebral inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in a chronic, immunologically mediated demyelinating disease that shares many features with human multiple sclerosis. CD4+ T lymphocytes play a critical rule in the pathogenesis of virus-induced demyelinating disease. We have identified a region within amino acid residues 24 to 37 of the VP3 capsid protein of TMEV (VP324-37) that is recognized by T lymphocytes from the demyelination-susceptible SJL/J strain of mice. The T-cell response to VP324-37 represents a predominant Th-cell response against the virus from either TMEV-immunized or TMEV- infected SJL/J mice, and vital epitopes VP1233-250, VP274-86, and VP324-37 account for most of the Th-cell response to TMEV.

Original languageEnglish (US)
Pages (from-to)7315-7318
Number of pages4
JournalJournal of virology
Volume69
Issue number11
DOIs
StatePublished - Nov 1995

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Fingerprint Dive into the research topics of 'Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice'. Together they form a unique fingerprint.

  • Cite this