Intracerebral inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in a chronic, immunologically mediated demyelinating disease that shares many features with human multiple sclerosis. CD4+ T lymphocytes play a critical rule in the pathogenesis of virus-induced demyelinating disease. We have identified a region within amino acid residues 24 to 37 of the VP3 capsid protein of TMEV (VP324-37) that is recognized by T lymphocytes from the demyelination-susceptible SJL/J strain of mice. The T-cell response to VP324-37 represents a predominant Th-cell response against the virus from either TMEV-immunized or TMEV- infected SJL/J mice, and vital epitopes VP1233-250, VP274-86, and VP324-37 account for most of the Th-cell response to TMEV.
ASJC Scopus subject areas
- Insect Science