Identification of a new metabolite of l-homocitrulline

S. C. Gates, N. Dendramis, R. W. Wilson*, A. F. Kohrman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Following the intraperitoneal injection of l-homocitrulline into rats a previously undescribed metabolite of this amino acid was detected in the urine. A compound with identical properties could also be prepared with l-amino acid oxidase. Mass spectrometric studies indicated that both of these derivatives had a molecular weight of 170.0690 and an empirical formula of C7H10O3N2. Upon exposure to acidic conditions the compound was converted a second form which had a molecular weight of 152.0585 and an empirical formula of C7H8O2N2. Nuclear magnetic resonance studies confirmed the cyclic structure of the unknown.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalBiochemical medicine
Volume18
Issue number1
DOIs
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Biochemistry

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