Identification of a new metabolite of l-homocitrulline

S. C. Gates, N. Dendramis, R. W. Wilson*, A. F. Kohrman

*Corresponding author for this work

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Abstract

Following the intraperitoneal injection of l-homocitrulline into rats a previously undescribed metabolite of this amino acid was detected in the urine. A compound with identical properties could also be prepared with l-amino acid oxidase. Mass spectrometric studies indicated that both of these derivatives had a molecular weight of 170.0690 and an empirical formula of C7H10O3N2. Upon exposure to acidic conditions the compound was converted a second form which had a molecular weight of 152.0585 and an empirical formula of C7H8O2N2. Nuclear magnetic resonance studies confirmed the cyclic structure of the unknown.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalBiochemical medicine
Volume18
Issue number1
DOIs
Publication statusPublished - Aug 1977

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ASJC Scopus subject areas

  • Biochemistry

Cite this

Gates, S. C., Dendramis, N., Wilson, R. W., & Kohrman, A. F. (1977). Identification of a new metabolite of l-homocitrulline. Biochemical medicine, 18(1), 87-95. https://doi.org/10.1016/0006-2944(77)90053-9