Abstract
Memory formation, maintenance, and retrieval are a dynamic process, reflecting a combined outcome of new memory formation on one hand, and older memory suppression/clearance on the other. Although much knowledge has been gained regarding new memory formation, less is known about the molecular components and processes that serve the function of memory suppression/ clearance. Here, we report the identification of a novel protein, termed hippyragranin (HGN), that is expressed in the rat hippocampus and its expression is reduced by hippocampal denervation. Inhibition of HGN by antisense oligonucleotide in area CA1 results in enhanced performance in Morris water maze, as well as elevated long-term potentiation. These results suggest that HGN is involved in negative memory regulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 418-424 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 334 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 26 2005 |
Funding
This work was supported in part by Life Science Special Fund of Chinese Academy of Sciences for Human Genome Research (KJ95T-06 and KSCX1-Y02 to M.J., N.J., and B.L.), National Natural Science Foundation of China (Grants #90208011, #30300174, #30470856, and #30421005 to N.J., #39970244, #30225023, and #30430240 to B.L.), National Key Basic Research and Development Program of China (G1999054000 to N.J. and B.L., and 2002CB713802 to N.J.), Shanghai Key Project of Basic Science Research (04DZ14005 to N.J. and B.L., and 04DZ05608 to N.J.), National High-Tech Research and Development Program of China (2002AA223081 to B.L.), and the National Institutes of Health (USA) grants (DA09444 and DA13471 to L.Y.).
Keywords
- Antisense oligonucleotide
- Hippyragranin
- LTP
- Negative memory regulation
- Spatial memory
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology