Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell

C. Clayberger, R. H. DeKruyff, R. Fay, H. Cantor

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We describe a cloned dendritic cell, clone Den-1, which is a potent accessory cell for some B-cell responses. Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators. This clone or factors produced by it also stimulate purified B cells to develop plaque-forming cell responses to type 2 antigens. The effect of this factor(s) on various B-cell populations and its relationship to previously described B-cell stimulating factors is discussed.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number1
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • General

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