Identification of bacterial and viral codetections with Mycoplasma pneumoniae using the TaqMan Array Card in patients hospitalized with community-acquired pneumonia

Maureen H. Diaz, Kristen E. Cross, Alvaro J. Benitez, Lauri A. Hicks, Preeta Kutty, Anna M. Bramley, James D. Chappell, Weston Hymas, Anami Patel, Chao Qi, Derek J. Williams, Sandra R. Arnold, Krow Ampofo, Wesley H. Self, Carlos G. Grijalva, Evan J. Anderson, Jonathan A. McCullers, Andrew T. Pavia, Richard G. Wunderink, Kathryn M. EdwardsSeema Jain, Jonas M. Winchell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Mycoplasma pneumoniae was detected in a number of patients with community-acquired pneumonia in a recent prospective study. To assess whether other pathogens were also detected in these patients, TaqMan Array Cards were used to test 216 M pneumoniae-positive respiratory specimens for 25 additional viral and bacterial respiratory pathogens. It is interesting to note that 1 or more codetections, predominantly bacterial, were identified in approximately 60% of specimens, with codetections being more common in children. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume3
Issue number2
DOIs
StatePublished - Apr 1 2016

Funding

We thank the patients who graciously consented to participate in this study and all members of the Etiology of Pneumonia in the Community (EPIC) Study Team for their contributions. This work was supported by the Influenza Division in the National Center for Immunization and Respiratory Diseases at the Centers for Disease Control and Prevention through cooperative agreements with each study site and was based on a competitive research funding opportunity.

Keywords

  • Community-acquired pneumonia
  • Multipathogen detection
  • Mycoplasma pneumoniae

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology

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