Identification of Differential Tumor Subtypes of T1 Bladder Cancer

A. Gordon Robertson, Clarice S. Groeneveld, Brian Jordan, Xiquo Lin, Kimberly A. McLaughlin, Arighno Das, Leigh Ann Fall, Damiano Fantini, Timothy J. Taxter, Lauren S. Mogil, Sia Viborg Lindskrog, Lars Dyrskjøt, David J. McConkey, Robert S. Svatek, Aurélien de Reyniès, Mauro A.A. Castro, Joshua J. Meeks*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We identified and characterized expression subtypes of high-grade T1 bladder cancer that are biologically heterogeneous and have variable responses to bacillus Calmette-Guérin treatment. We validated the subtypes and describe a single-patient classifier.

Original languageEnglish (US)
Pages (from-to)533-537
Number of pages5
JournalEuropean urology
Volume78
Issue number4
DOIs
StatePublished - Oct 2020

Keywords

  • Bacillus Calmette-Guérin
  • Carcinoma in situ
  • Immune signatures
  • Luminal
  • Non–muscle-invasive bladder cancer
  • Tumor subtype

ASJC Scopus subject areas

  • Urology

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