Identification of Differential Tumor Subtypes of T1 Bladder Cancer

A. Gordon Robertson; Clarice S. Groeneveld; Brian Jordan; Xiquo Lin; Kimberly A. McLaughlin; Arighno Das; Leigh Ann Fall; Damiano Fantini; Timothy J. Taxter; Lauren S. Mogil; Sia Viborg Lindskrog; Lars Dyrskjøt; David J. McConkey; Robert S. Svatek; Aurélien de Reyniès; Mauro A.A. Castro; Joshua J. Meeks

doi:10.1016/j.eururo.2020.06.048

Identification of Differential Tumor Subtypes of T1 Bladder Cancer

A. Gordon Robertson, Clarice S. Groeneveld, Brian Jordan, Xiquo Lin, Kimberly A. McLaughlin, Arighno Das, Leigh Ann Fall, Damiano Fantini, Timothy J. Taxter, Lauren S. Mogil, Sia Viborg Lindskrog, Lars Dyrskjøt, David J. McConkey, Robert S. Svatek, Aurélien de Reyniès, Mauro A.A. Castro, Joshua J. Meeks^*

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

We identified and characterized expression subtypes of high-grade T1 bladder cancer that are biologically heterogeneous and have variable responses to bacillus Calmette-Guérin treatment. We validated the subtypes and describe a single-patient classifier.

Original language	English (US)
Pages (from-to)	533-537
Number of pages	5
Journal	European urology
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/j.eururo.2020.06.048
State	Published - Oct 2020

Keywords

Bacillus Calmette-Guérin
Carcinoma in situ
Immune signatures
Luminal
Non–muscle-invasive bladder cancer
Tumor subtype

ASJC Scopus subject areas

Urology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.eururo.2020.06.048

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Robertson, A. G., Groeneveld, C. S., Jordan, B., Lin, X., McLaughlin, K. A., Das, A., Fall, L. A., Fantini, D., Taxter, T. J., Mogil, L. S., Lindskrog, S. V., Dyrskjøt, L., McConkey, D. J., Svatek, R. S., de Reyniès, A., Castro, M. A. A., & Meeks, J. J. (2020). Identification of Differential Tumor Subtypes of T1 Bladder Cancer. European urology, 78(4), 533-537. https://doi.org/10.1016/j.eururo.2020.06.048

@article{6b2d3f5374894275a852d17a8855c470,

title = "Identification of Differential Tumor Subtypes of T1 Bladder Cancer",

abstract = "We identified and characterized expression subtypes of high-grade T1 bladder cancer that are biologically heterogeneous and have variable responses to bacillus Calmette-Gu{\'e}rin treatment. We validated the subtypes and describe a single-patient classifier.",

keywords = "Bacillus Calmette-Gu{\'e}rin, Carcinoma in situ, Immune signatures, Luminal, Non–muscle-invasive bladder cancer, Tumor subtype",

author = "Robertson, {A. Gordon} and Groeneveld, {Clarice S.} and Brian Jordan and Xiquo Lin and McLaughlin, {Kimberly A.} and Arighno Das and Fall, {Leigh Ann} and Damiano Fantini and Taxter, {Timothy J.} and Mogil, {Lauren S.} and Lindskrog, {Sia Viborg} and Lars Dyrskj{\o}t and McConkey, {David J.} and Svatek, {Robert S.} and {de Reyni{\`e}s}, Aur{\'e}lien and Castro, {Mauro A.A.} and Meeks, {Joshua J.}",

note = "Funding Information: Funding/Support and role of the sponsor: Joshua J. Meeks is supported by grants from VHA (BX003692-01), DoD (W81XWH-18-0257), the Dixon Foundation, and a HOPE Foundation SEED award. The sponsors played a role in the design and conduct of the study. Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = oct,

doi = "10.1016/j.eururo.2020.06.048",

language = "English (US)",

volume = "78",

pages = "533--537",

journal = "European Urology",

issn = "0302-2838",

publisher = "Elsevier",

number = "4",

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Robertson, AG, Groeneveld, CS, Jordan, B, Lin, X, McLaughlin, KA, Das, A, Fall, LA, Fantini, D, Taxter, TJ, Mogil, LS, Lindskrog, SV, Dyrskjøt, L, McConkey, DJ, Svatek, RS, de Reyniès, A, Castro, MAA & Meeks, JJ 2020, 'Identification of Differential Tumor Subtypes of T1 Bladder Cancer', European urology, vol. 78, no. 4, pp. 533-537. https://doi.org/10.1016/j.eururo.2020.06.048

TY - JOUR

T1 - Identification of Differential Tumor Subtypes of T1 Bladder Cancer

AU - Robertson, A. Gordon

AU - Groeneveld, Clarice S.

AU - Jordan, Brian

AU - Lin, Xiquo

AU - McLaughlin, Kimberly A.

AU - Das, Arighno

AU - Fall, Leigh Ann

AU - Fantini, Damiano

AU - Taxter, Timothy J.

AU - Mogil, Lauren S.

AU - Lindskrog, Sia Viborg

AU - Dyrskjøt, Lars

AU - McConkey, David J.

AU - Svatek, Robert S.

AU - de Reyniès, Aurélien

AU - Castro, Mauro A.A.

AU - Meeks, Joshua J.

N1 - Funding Information: Funding/Support and role of the sponsor: Joshua J. Meeks is supported by grants from VHA (BX003692-01), DoD (W81XWH-18-0257), the Dixon Foundation, and a HOPE Foundation SEED award. The sponsors played a role in the design and conduct of the study. Publisher Copyright: © 2020

PY - 2020/10

Y1 - 2020/10

N2 - We identified and characterized expression subtypes of high-grade T1 bladder cancer that are biologically heterogeneous and have variable responses to bacillus Calmette-Guérin treatment. We validated the subtypes and describe a single-patient classifier.

AB - We identified and characterized expression subtypes of high-grade T1 bladder cancer that are biologically heterogeneous and have variable responses to bacillus Calmette-Guérin treatment. We validated the subtypes and describe a single-patient classifier.

KW - Bacillus Calmette-Guérin

KW - Carcinoma in situ

KW - Immune signatures

KW - Luminal

KW - Non–muscle-invasive bladder cancer

KW - Tumor subtype

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U2 - 10.1016/j.eururo.2020.06.048

DO - 10.1016/j.eururo.2020.06.048

M3 - Article

C2 - 32684305

AN - SCOPUS:85087960964

SN - 0302-2838

VL - 78

SP - 533

EP - 537

JO - European Urology

JF - European Urology

IS - 4

ER -

Identification of Differential Tumor Subtypes of T1 Bladder Cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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