Identification of Fat4 as a candidate tumor suppressor gene In breast cancers

Qi Chao, Tony Zhu Yiwei, Hu Liping, Yi Jun Zhu

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Fat, a candidate tumor suppressor in Drosophila, is a component of Hippo signaling pathway involved in controlling organ size. We found that a ∼3 Mbp deletion in mouse chromosome 3 caused tu-morigenesis of a non-tumorigenie mammary epithelial cell line. The expression of Fat4 gene, one member of the Fat family, in the deleted region was inactivated, which resulted from promoter methylation of another Fat4 allele following the deletion of one Fat4 allele. Re-expression of Fat4 in Fat4-deicient tumor cells suppressed the tumorigeneeity whereas suppression of Fat4 expression in the non-tumorigenic mammary epithelial cell line induced tumorigenesis. We also found that Fat4 expression was lost in a large fraction of human breast tumor cell lines and primary tumors. Loss of Fat4 expression in breast tumors was associated with human Fat4 promoter methylation. Together, these findings suggest that Fat4 is a strong candidate for a breast tumor suppressor gene.

Original languageEnglish (US)
Pages (from-to)793-798
Number of pages6
JournalInternational Journal of Cancer
Volume124
Issue number4
DOIs
StatePublished - Feb 15 2009

Keywords

  • Breast cancer
  • Hippo signaling
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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