Identification of genes contributing to the obese yellow Avy phenotype: Caloric restriction, genotype, diet X genotype interactions

Jim Kaput*, Karin G. Klein, Eric J. Reyes, Warren A. Kibbe, Craig A. Cooney, Borko Jovanovic, Willard J. Visek, George L. Wolff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. Avy/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr X VYWffC3Hf/Nctr-A vy/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet X genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.

Original languageEnglish (US)
Pages (from-to)316-324
Number of pages9
JournalPhysiological genomics
Volume18
DOIs
StatePublished - Oct 2004

Keywords

  • Diabesity
  • Diabetes
  • Expression
  • Gene regulation
  • Obesity
  • Quantitative trait locus

ASJC Scopus subject areas

  • Physiology
  • Genetics

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