Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities

Y. Wan, M. W. Kirschner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


CDC20/CDH1 activates the anaphase-promoting complex (APC) and targets various substrates for degradation, thereby allowing the ordered progression through mitosis and G1. We have found multiple functional CDH1 homologues in the chick. The transcripts of these novel genes are differentially localized to proliferating, differentiated, and postmitotic tissues. All four proteins bind and form a complex with APC in vitro and in cultural cells and have quantitatively different activities in mediating ubiquitination of various APC substrates. Our results suggest that multiple CDH1s may temporally and spatially regulate APC activity both within and outside of the cell cycle.

Original languageEnglish (US)
Pages (from-to)13066-13071
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number23
StatePublished - Nov 6 2001


  • Anaphase-promoting complex
  • Degradation
  • Ubiquitin

ASJC Scopus subject areas

  • General


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