Identification of Pharmacoresistant Epilepsy

Anne T. Berg

doi:10.1016/j.ncl.2009.06.001

Identification of Pharmacoresistant Epilepsy

Anne T. Berg^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

There is no single definition of pharmacoresistant (intractable, refractory) epilepsy. Prospective identification of pharmacoresistance is complicated by the variability of its appearance across different types of epilepsy and the variability of seizure control within a given patient over time. Failure of informative trials of two appropriate antiepileptic drugs has been recommended as a threshold that should trigger referral for evaluation at a comprehensive epilepsy center. Maximizing seizure control is imperative for reducing the risks and consequences of epilepsy, including the cognitive and psychiatric comorbidities and even sudden death.

Original language	English (US)
Pages (from-to)	1003-1013
Number of pages	11
Journal	Neurologic clinics
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.ncl.2009.06.001
State	Published - Nov 2009

Funding

This work was supported by Grant R37-31146 from the NIH-NINDS.

Keywords

Antiepileptic drugs
Definitions
Epileptic encephalopathy
Methodology
Natural history
Surgery

ASJC Scopus subject areas

Clinical Neurology

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10.1016/j.ncl.2009.06.001

Cite this

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AB - There is no single definition of pharmacoresistant (intractable, refractory) epilepsy. Prospective identification of pharmacoresistance is complicated by the variability of its appearance across different types of epilepsy and the variability of seizure control within a given patient over time. Failure of informative trials of two appropriate antiepileptic drugs has been recommended as a threshold that should trigger referral for evaluation at a comprehensive epilepsy center. Maximizing seizure control is imperative for reducing the risks and consequences of epilepsy, including the cognitive and psychiatric comorbidities and even sudden death.

KW - Antiepileptic drugs

KW - Definitions

KW - Epileptic encephalopathy

KW - Methodology

KW - Natural history

KW - Surgery

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ER -

Identification of Pharmacoresistant Epilepsy

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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