Identification of proliferative progenitors associated with prominent postnatal growth of the pons

Robert A. Lindquist, Cristina D. Guinto, Jose L. Rodas-Rodriguez, Luis C. Fuentealba, Matthew C. Tate, David H. Rowitch, Arturo Alvarez-Buylla*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The pons controls crucial sensorimotor and autonomic functions. In humans, it grows sixfold postnatally and is a site of paediatric gliomas; however, the mechanisms of pontine growth remain poorly understood. We show that the murine pons quadruples in volume postnatally; growth is fastest during postnatal days 0-4 (P0-P4), preceding most myelination. We identify three postnatal proliferative compartments: ventricular, midline and parenchymal. We find no evidence of postnatal neurogenesis in the pons, but each progenitor compartment produces new astroglia and oligodendroglia; the latter expand 10- to 18-fold postnatally, and are derived mostly from the parenchyma. Nearly all parenchymal progenitors at P4 are Sox2 + Olig2 +, but by P8 a Sox2 a' subpopulation emerges, suggesting a lineage progression from Sox2 + aearlya to Sox2 a' alatea oligodendrocyte progenitor. Fate mapping reveals that >90% of adult oligodendrocytes derive from P2-P3 Sox2 + progenitors. These results demonstrate the importance of postnatal Sox2 + Olig2 + progenitors in pontine growth and oligodendrogenesis.

Original languageEnglish (US)
Article number11628
JournalNature communications
Volume7
DOIs
StatePublished - May 18 2016

Fingerprint

Pons
Oligodendroglia
compartments
Growth
Pediatrics
Neurogenesis
Glioma
progressions
Astrocytes

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Lindquist, R. A., Guinto, C. D., Rodas-Rodriguez, J. L., Fuentealba, L. C., Tate, M. C., Rowitch, D. H., & Alvarez-Buylla, A. (2016). Identification of proliferative progenitors associated with prominent postnatal growth of the pons. Nature communications, 7, [11628]. https://doi.org/10.1038/ncomms11628
Lindquist, Robert A. ; Guinto, Cristina D. ; Rodas-Rodriguez, Jose L. ; Fuentealba, Luis C. ; Tate, Matthew C. ; Rowitch, David H. ; Alvarez-Buylla, Arturo. / Identification of proliferative progenitors associated with prominent postnatal growth of the pons. In: Nature communications. 2016 ; Vol. 7.
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Lindquist, RA, Guinto, CD, Rodas-Rodriguez, JL, Fuentealba, LC, Tate, MC, Rowitch, DH & Alvarez-Buylla, A 2016, 'Identification of proliferative progenitors associated with prominent postnatal growth of the pons', Nature communications, vol. 7, 11628. https://doi.org/10.1038/ncomms11628

Identification of proliferative progenitors associated with prominent postnatal growth of the pons. / Lindquist, Robert A.; Guinto, Cristina D.; Rodas-Rodriguez, Jose L.; Fuentealba, Luis C.; Tate, Matthew C.; Rowitch, David H.; Alvarez-Buylla, Arturo.

In: Nature communications, Vol. 7, 11628, 18.05.2016.

Research output: Contribution to journalArticle

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