Identification of traits and functional connectivity-based neurotraits of chronic pain

Etienne Vachon-Presseau, Sara E. Berger, Taha B. Abdullah, James W Griffith, Thomas J Schnitzer, Apkar Apkarian

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Psychological and personality factors, socioeconomic status, and brain properties all contribute to chronic pain but have essentially been studied independently. Here, we administered a broad battery of questionnaires to patients with chronic back pain (CBP) and collected repeated sessions of resting-state functional magnetic resonance imaging (fMRI) brain scans. Clustering and network analyses applied on the questionnaire data revealed four orthogonal dimensions accounting for 56% of the variance and defining chronic pain traits. Two of these traits—Pain-trait and Emote-trait—were associated with back pain characteristics and could be related to distinct distributed functional networks in a cross-validation procedure, identifying neurotraits. These neurotraits showed good reliability across four fMRI sessions acquired over five weeks. Further, traits and neurotraits all related to the income, emphasizing the importance of socioeconomic status within the personality space of chronic pain. Our approach is a first step in providing metrics aimed at unifying the psychology and the neurophysiology of chronic pain applicable across diverse clinical conditions.

Original languageEnglish (US)
Article numbere3000349
JournalPLoS biology
Volume17
Issue number8
DOIs
StatePublished - Aug 20 2019

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Chronic Pain
pain
Brain
Neurophysiology
Back Pain
Social Class
Personality
socioeconomic status
magnetic resonance imaging
Magnetic Resonance Imaging
Psychology
questionnaires
brain
neurophysiology
psychology
back (body region)
Cluster Analysis
income
Surveys and Questionnaires

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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Identification of traits and functional connectivity-based neurotraits of chronic pain. / Vachon-Presseau, Etienne; Berger, Sara E.; Abdullah, Taha B.; Griffith, James W; Schnitzer, Thomas J; Apkarian, Apkar.

In: PLoS biology, Vol. 17, No. 8, e3000349, 20.08.2019.

Research output: Contribution to journalArticle

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AU - Vachon-Presseau, Etienne

AU - Berger, Sara E.

AU - Abdullah, Taha B.

AU - Griffith, James W

AU - Schnitzer, Thomas J

AU - Apkarian, Apkar

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