Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies

M. Geoffrey Hayes, Anna Pluzhnikov, Kazuaki Miyake, Ying Sun, Maggie C Y Ng, Cheryl A. Roe, Jennifer E. Below, Raluca I. Nicolae, Anuar Konkashbaev, Graeme I. Bell, Nancy J. Cox*, Craig L. Hanis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

OBJECTIVE - The objective of this study was to identify DNA polymorphisms associated with type 2 diabetes in a Mexican-American population. RESEARCH DESIGN AND METHODS - We genotyped 116,204 single nucleotide polymorphisms (SNPs) in 281 Mexican Americans with type 2 diabetes and 280 random Mexican Americans from Starr County, Texas, using the Affymetrix GeneChip Human Mapping 100K set. Allelic association exact tests were calculated. Our most significant SNPs were compared with results from other type 2 diabetes genome-wide association studies (GWASs). Proportions of African, European, and Asian ancestry were estimated from the HapMap samples using structure for each individual to rule out spurious association due to population substructure. RESULTS - We observed more significant allelic associations than expected genome wide, as empirically assessed by permutation (14 below a P of 1 × 10-4 [8.7 expected]). No significant differences were observed between the proportion of ancestry estimates in the case and random control sets, suggesting that the association results were not likely confounded by substructure. A query of our top ∼1% of SNPs (P < 0.01) revealed SNPs in or near four genes that showed evidence for association (P < 0.05) in multiple other GWAS interrogated: rs979752 and rs10500641 near UBQLNL and OR52H1 on chromosome 11, rs2773080 and rs3922812 in or near RALGPS2 on chromosome 1, and rs1509957 near EGR2 on chromosome 10. CONCLUSIONS - We identified several SNPs with suggestive evidence for replicated association with type 2 diabetes that merit further investigation.

Original languageEnglish (US)
Pages (from-to)3033-3044
Number of pages12
JournalDiabetes
Volume56
Issue number12
DOIs
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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