Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy

Katarzyna Rojek, Eric Nickels, Barbara Neistadt, Rafael Marquez, Amittha Wickrema, Andrew Artz, Koen van Besien, Richard A. Larson, Ming K. Lee, Jeremy P. Segal, Mary Claire King, Tom Walsh, Akiko Shimamura, Sioban B. Keel, Jane E. Churpek, Lucy A. Godley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Analysis of the clinical characteristics of hematopoietic stem cell transplant (HSCT) donors has proven beneficial for identifying cases of heritable hematopoietic disorders. This study examines poor peripheral blood hematopoietic stem cell mobilization after granulocyte colony–stimulating factor administration among 328 donors as a potential marker for suspected familial predisposition to myeloid malignancies. Here, we present data comparing the clinical characteristics of poor-mobilizing versus nonpoor-mobilizing donors and the results of panel-based sequencing of hematopoietic genes in poor-mobilizing donors. From this analysis, we identified a novel case of a donor-derived myelodysplastic syndrome in an HSCT recipient that is consistent with clonal evolution of TET2-mutated clonal hematopoiesis of indeterminate potential (CHIP) within the donor. This study demonstrates the potential risk of using hematopoietic stem cells from a donor with CHIP and raises the question of whether there should be increased screening measures to identify such donors.

Original languageEnglish (US)
Pages (from-to)2100-2103
Number of pages4
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • Clonal hematopoiesis of indeterminate potential
  • Donor-derived leukemia
  • TET2 mutation

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Fingerprint

Dive into the research topics of 'Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy'. Together they form a unique fingerprint.

Cite this