Identifying Patients for Aggressive Cholesterol Lowering: The Risk Curve Concept

Jennifer G. Robinson*, Neil J. Stone

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

39 Scopus citations


The National Cholesterol Education Program's 2004 report identified more aggressive optional low-density lipoprotein (LDL) cholesterol treatment goals of <70 mg/dl for secondary prevention patients and <100 mg/dl for moderately high risk, primary prevention patients. Although LDL cholesterol reduction is the first step in reducing cardiovascular risk, it may be difficult for clinicians to visualize the risk reduction benefit for patients from various risk interventions. The concept of a "risk curve," or the absolute risk of a patient for subsequent cardiovascular events over a range of LDL cholesterol values, is proposed. In conclusion, placing a patient on the appropriate risk curve may facilitate an individualized clinical management strategy that takes into account the patient's absolute benefit from further LDL cholesterol reduction as well as from shifting the risk curve downward through non-LDL cholesterol interventions.

Original languageEnglish (US)
Pages (from-to)1405-1408
Number of pages4
JournalAmerican Journal of Cardiology
Issue number10
StatePublished - Nov 15 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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