Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data

Answer ALS, Pooled Resource Open-Access Als Clinical Trials Consortium, ALS/MND Natural History Consortium

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The clinical presentation of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, varies widely across patients, making it challenging to determine if potential therapeutics slow progression. We sought to determine whether there were common patterns of disease progression that could aid in the design and analysis of clinical trials. We developed an approach based on a mixture of Gaussian processes to identify clusters of patients sharing similar disease progression patterns, modeling their average trajectories and the variability in each cluster. We show that ALS progression is frequently nonlinear, with periods of stable disease preceded or followed by rapid decline. We also show that our approach can be extended to Alzheimer’s and Parkinson’s diseases. Our results advance the characterization of disease progression of ALS and provide a flexible modeling approach that can be applied to other progressive diseases.

Original languageEnglish (US)
Pages (from-to)605-616
Number of pages12
JournalNature Computational Science
Issue number9
StatePublished - Sep 2022

ASJC Scopus subject areas

  • Computer Science (miscellaneous)
  • Computer Science Applications
  • Computer Networks and Communications


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