Identifying the 3′-terminal exon in human DNA

Jack E. Tabaska, Ramana V. Davuluri, Michael Q. Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Motivation: We present JTEF, a new program for finding 3′ terminal exons in human DNA sequences. This program is based on quadratic discriminant analysis, a standard non-linear statistical pattern recognition method. The quadratic discriminant functions used for building the algorithm were trained on a set of 3′ terminal exons of type 3tuexon (those containing the true STOP codon). Results: We showed that the average predictive accuracy of JTEF is higher than the presently available best programs (GenScan and Genemark.hmm) based on a test set of 65 human DNA sequences with 121 genes. In particular JTEF performs well on larger genomic contigs containing multiple genes and significant amounts of intergenic DNA. It will become a valuable tool for genome annotation and gene functional studies.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalBioinformatics
Volume17
Issue number7
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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