Identifying the reproductive toxicity of biocompatible 3d-printed dental resins

With the development of more sophisticated manufacturing techniques, biomaterials are increasingly being developed and used in biomedical research, including in reproductive science and medicine. One aspect of new biomaterials that is often overlooked is the potential for adverse effects on reproductive health, such as gamete development and quality. Biomaterials frequently contain plastics or leachates that may appear to be biocompatible with respect to non-reproductive tissues but are later found to exhibit reproductive toxicity. As 3D-printing has become more accessible and printers have become more advanced, 3D-printing technology is a promising resource for the creation of new biomedical devices. However, the resins currently available for most printers are still limited, with only a few that have been tested for their biocompatibility. The objective of this study was to test the potential reproductive toxicity of two commercially available 3D-printable dental resins that are currently marketed as biocompatible: Dental SG (DSG) and Dental LT (DLT). DSG is a Class I certified biocompatible material meant for printing custom surgical guides. DLT is a Class IIa certified biocompatible material that is designed for printing oral retainers, and therefore extended human contact.