Idiopathic anaphylaxis in children manifested as upper airway obstruction

Pediatric idiopathic anaphylaxis has previously been reported and medical management defined in 15 patients. We report 3 cases of pediatric idiopathic anaphylaxis, each sharing upper airway obstruction as one of the presenting symptoms. The patients were managed with a program of oral prednisone, sympathomimetics, antihistamines, and inhaled corticosteroids with a favorable outcome. Pediatric idiopathic anaphylaxis must be included in the differential diagnosis of children presenting with upper airway obstruction. Inhaled corticosteroids may provide a protective benefit from further episodes of airway obstruction due to idiopathic anaphylaxis.