IgA antibody against Aspergillus fumigatus antigen in patients with allergic bronchopulmonary aspergillosis

R. Patterson, M. Roberts, A. C. Ghory, Paul Allen Greenberger

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

IgA antibodies against Aspergillus fumigatus (Af) antigen were measured by a radioimmunoassay in sera from patients with allergic bronchopulmonary aspergillosis (ABPA) and compared with IgA antibody levels in asthmatics who had positive prick tests of Af and normal controls. The assay for IgA antibody discriminated between both control groups and the ABPA group at two serum dilutions (10-2 and 10-3) but did not discriminate all individual ABPA sera from the peak levels of antibody in the control groups. IgA antibody against Af may participate in the immunopathogenetics of pulmonary inflammation in some cases of ABPA and may be of some diagnostic value in some, but not all, cases.

Original languageEnglish (US)
Pages (from-to)395-398
Number of pages4
JournalClinical and Experimental Immunology
Volume42
Issue number2
StatePublished - Jan 1 1980

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Allergic Bronchopulmonary Aspergillosis
Aspergillus fumigatus
Immunoglobulin A
Antigens
Antibodies
Serum
Control Groups
Radioimmunoassay
Pneumonia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "IgA antibodies against Aspergillus fumigatus (Af) antigen were measured by a radioimmunoassay in sera from patients with allergic bronchopulmonary aspergillosis (ABPA) and compared with IgA antibody levels in asthmatics who had positive prick tests of Af and normal controls. The assay for IgA antibody discriminated between both control groups and the ABPA group at two serum dilutions (10-2 and 10-3) but did not discriminate all individual ABPA sera from the peak levels of antibody in the control groups. IgA antibody against Af may participate in the immunopathogenetics of pulmonary inflammation in some cases of ABPA and may be of some diagnostic value in some, but not all, cases.",
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IgA antibody against Aspergillus fumigatus antigen in patients with allergic bronchopulmonary aspergillosis. / Patterson, R.; Roberts, M.; Ghory, A. C.; Greenberger, Paul Allen.

In: Clinical and Experimental Immunology, Vol. 42, No. 2, 01.01.1980, p. 395-398.

Research output: Contribution to journalArticle

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