IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease

Anne H. Rowley, Stanford T. Shulman, Carrie A. Mask, Laura S. Finn, Masaru Terai, Susan C. Baker, Carlos A. Galliani, Kei Takahashi, Shiro Naoe, Mitra B. Kalelkar, Susan E. Crawford

Research output: Contribution to journalArticlepeer-review

142 Scopus citations

Abstract

The etiology and pathogenesis of Kawasaki disease (KD) remain unknown. As previously reported, in US patients with acute KD, IgA plasma cells (PCs) infiltrate the vascular wall. To determine whether IgA PCs are increased at mucosal sites in KD and to determine whether other nonvascular KD tissues are infiltrated by IgA PCs, the cells were immunolocalized and quantitated in tissue sections taken from 18 US and Japanese patients who died of acute KD and from 10 age-matched controls. IgA PCs were significantly increased in the trachea of patients who died of acute KD, compared with controls (P < .01), a finding that was similar to findings in children with fatal respiratory viral infection. IgA PCs also infiltrated coronary artery, pancreas, and kidney in all KD patients. These findings strongly support entry of the KD etiologic agent through the upper respiratory tract, resulting in an IgA immune response, with systemic spread to vascular tissue, pancreas, and kidney.

Original languageEnglish (US)
Pages (from-to)1183-1191
Number of pages9
JournalJournal of Infectious Diseases
Volume182
Issue number4
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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