IgE against ethylene oxide-altered human serum albumin in patients with anaphylactic reactions to dialysis

Leslie C. Grammer*, Bruce F. Paterson, David Roxe, John T. Daugirdas, Todd S. Ing, Peter T. Ivanovich, Colin B. Brown, Anthony J. Nicholls, Roy Patterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

We have measured total antibody and IgE directed against ethylene oxide-altered human serum albumin (ETO-HSA) in the sera of 24 patients who have experienced anaphylaxis during hemodialysis and of 41 patients who have not had such episodes during hemodialysis. ETO is used to sterilize dialyzers and other medical equipment. The geometric mean level of IgE to ETO-HSA in patients with reactions (0.9 ng ETO-HSA bound to IgE per milliliter of serum) is significantly higher than in nonreacting patients (0.1 ng/ml, p < 0.0001). Sixteen of 24 patients with reactions had detectable levels of IgE to ETO-HSA, whereas only three of 41 nonreacting patients had detectable levels, (p < 0.0001 chi-square). The geometric mean level of total antibody to ETO-HSA is also significantly higher in patients with reactions (270 ng ETO-HSA bound per milliliter) than in nonreacting patients (31 ng/ml, p < 0.0001). Fourteen of 24 patients with reactions but only four of 39 nonreacting patients had total antibody binding of ETO-HSA (p < 0.0001 chi-square). These data extend our previous observations on a small group of 13 patients receiving hemodialysis (seven patients with reactions, and six nonreacting patients) and clearly demonstrate an association between the presence of IgE or total antibody to ETO-HSA and immediate anaphylactic reactions in this group of 65 patients receiving hemodialysis.

Original languageEnglish (US)
Pages (from-to)511-514
Number of pages4
JournalThe Journal of allergy and clinical immunology
Volume76
Issue number3
DOIs
StatePublished - Sep 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'IgE against ethylene oxide-altered human serum albumin in patients with anaphylactic reactions to dialysis'. Together they form a unique fingerprint.

Cite this