IGF-1, IGFBP-3, and nutritional factors in young black and white men: The CARDIA Male Hormone Study

Laura A. Colangelo, Brian C.H. Chiu, Kiang Liu, Peter A. Kopp, Peter H. Gann, Susan M. Gapstur*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Nutritional factors might play a role in regulating serum levels of insulin-like growth factors (IGFs), which are associated with some cancers. We examined the associations of nutritional factors with IGF-1 and IGF binding protein-3 (IGFBP-3). Serum IGF-1 and IGFBP-3 levels and dietary intake were measured in 459 black and 682 white male subjects of the Coronary Artery Risk Development in Young Adults study at the Year 7 (1992-1993) exam. Analysis of covariance and multivariable linear regression were used to assess associations of IGFs with dietary factors by race. IGF-1 was positively associated with magnesium in both black and white men (P = 0.008 and 0.05, respectively). Calcium was positively significantly related to IGF-1 in black men (P = 0.04) and marginally so in white men (P = 0.09). In black men, IGFBP-3 was positively associated with magnesium (P = 0.02), and one serving of milk per day was associated with an 8.23-ng/ml higher IGF-1 concentration (P = 0.05). Tests for interaction, however, revealed no differences between blacks and whites in the associations of nutrients with IGF-1 or IGFBP-3. In conclusion, the associations of dietary factors with serum IGF-1 and IGFBP-3 observed in our study corroborate those from other studies and generally do not differ between black and white men.

Original languageEnglish (US)
Pages (from-to)57-64
Number of pages8
JournalNutrition and Cancer
Volume53
Issue number1
DOIs
StatePublished - 2005

Funding

This research was supported by U.S. Public Health Service grant RO1-CA770403 from the National Cancer Institute and U.S. Public Health Service contracts NO1-HC-48047, NO1-HC-48048, NO1-HC-48049, NO1-HC-48050, and NO1-HC-95095 from the National Heart, Lung and Blood Institute. Address correspondence to Susan M. Gapstur, PhD, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1102, Chicago, IL 60611. Phone: (312) 908-0306. FAX: (312) 908–9588. E-mail: [email protected].

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Oncology
  • Cancer Research
  • Medicine (miscellaneous)

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