IgG antibody against formaldehyde human serum proteins: A comparison with other IgG antibodies against inhalant proteins and reactive chemicals

Roy Patterson*, Mark S. Dykewicz, Richard Evans, Leslie C. Grammer, Paul A. Greenberger, Kathleen E. Harris, Ira D. Lawrence, Jacob J. Pruzansky, Mary Roberts, Martha A. Shaughnessy, C. Raymond Zeiss

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Immune responses to formaldehyde (F) have been recorded for seven decades. More recently, sensitive assays for antibody against F-human serum albumin (HSA) have been reported. IgG antibody against F-HSA has been said to correlate with symptoms against F-HSA. We report on 61 serum samples analyzed for IgG antibodies against F-HSA. IgG antibodies against F-HSA were most prevalent in subjects who had received intravenous F. In no case (either presumed symptomatic to F or with IgG antibody against F-HSA) was there a correlation of serologic results with symptoms. We also reviewed inhalation disease caused by chemicals and proteins acting as immunogens and report that at this time there is no evidence that gaseous F meets the criteria for causation of inhalational IgG-mediated lung disease by clinical or serologic studies. Very high IgG antibody levels occur in respiratory immunologic inhalational disease, and the absence of these high IgG levels against F is strong evidence against F or F proteins being an inhalational antigen of significance.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalThe Journal of allergy and clinical immunology
Volume84
Issue number3
DOIs
StatePublished - Sep 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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