IgG rheumatoid factor

Richard M. Pope*, Sandra J. Mcduffy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


IgG rheumatoid factor was detected in the sera of the majority of patients with seropositive rheumatoid arthritis. Values suggestive of IgG rheumatoid factor were noted in one‐quarter of patients with seronegative inflammatory arthropathies. These determinations were always low and correlated with elevated IgG concentrations, suggesting nonspecific adherence of IgG rather than a true antigen‐antibody reaction. In support of this conclusion, nonrheumatoid factor IgG was capable of concentration‐dependent nonspecific adsorption to the solid phase. IgG, but not IgM, rheumatoid factor corresponded with disease activity in patients with seropositive rheumatoid arthritis, suggesting that IgG rheumatoid factor may be important in the pathogenesis.

Original languageEnglish (US)
Pages (from-to)988-998
Number of pages11
JournalArthritis & Rheumatism
Issue number9
StatePublished - Sep 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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