Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T Cell Development

Larry Y. Wong, Julianne K. Hatfield, Melissa Ann Brown*

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: Ikaros regulates early hematopoietic cell differentiation. Results: Th17 cell differentiation is impaired in Ikaros -/- cells because of repressive and irreversible chromatin marks within lineage-determining genes. Conclusion: Ikaros acts to integrate Th17 polarizing signals, activating essential genes and repressing genes that limit differentiation. Significance: Ikaros plays a critical role in shaping CD4 + T cell fates in the periphery in response to acute activation signals.

Original languageEnglish (US)
Pages (from-to)35170-35179
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number49
DOIs
StatePublished - Dec 6 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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