IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and γδ T cells in vivo

Jeong Su Do, Booki Min*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that γδ T cells limit CD8 T-cell expansion but not the initial proliferation after transfer into lymphopenic recipients. Interleukin-15 (IL-15) produced by and transpresented on the membrane of the CD11c+ dendritic cells (DCs) is the key factor that mediates homeostatic competition between CD8 and γδ T cells, revealing previously unrecognized IL-15-dependent homeostatic mechanisms between different T-cell subsets in vivo.

Original languageEnglish (US)
Pages (from-to)6361-6371
Number of pages11
JournalBlood
Volume113
Issue number25
DOIs
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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