Abstract
Over the years, interleukin (IL)-27 has received much attention because of its highly divergent, sometimes even opposing, functions in immunity. IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions. Furthermore, there is emerging evidence that IL-30 itself may perform immunomodulatory functions independent of Ebi3 or other binding partners and that IL-30 production is strongly associated with certain cancers in humans. In this review, we will discuss the biology of IL-30 and other IL-30-associated cytokines and their functions in inflammation and cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 823-834 |
| Number of pages | 12 |
| Journal | Experimental and Molecular Medicine |
| Volume | 53 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2021 |
Funding
We are grateful to Isabel Aschenbrenner, TUM, for preparing Fig. 1. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (R01-AI125247 and R01-AI147498 to B.M.), National Multiple Sclerosis Society (RG-1806-31374 and RG-1411-02051 to B.M.), and SFB1035 (German Research Foundation DFG, Sonderforschungsbereich 1035, Projektnummer 201302640, project B11 to M.J.F.).
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Biochemistry
- Clinical Biochemistry
