TY - JOUR
T1 - IL-30† (IL-27A)
T2 - a familiar stranger in immunity, inflammation, and cancer
AU - Min, Booki
AU - Kim, Dongkyun
AU - Feige, Matthias J.
N1 - Funding Information:
We are grateful to Isabel Aschenbrenner, TUM, for preparing Fig. 1. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (R01-AI125247 and R01-AI147498 to B.M.), National Multiple Sclerosis Society (RG-1806-31374 and RG-1411-02051 to B.M.), and SFB1035 (German Research Foundation DFG, Sonderforschungsbereich 1035, Projektnummer 201302640, project B11 to M.J.F.).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/5
Y1 - 2021/5
N2 - Over the years, interleukin (IL)-27 has received much attention because of its highly divergent, sometimes even opposing, functions in immunity. IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions. Furthermore, there is emerging evidence that IL-30 itself may perform immunomodulatory functions independent of Ebi3 or other binding partners and that IL-30 production is strongly associated with certain cancers in humans. In this review, we will discuss the biology of IL-30 and other IL-30-associated cytokines and their functions in inflammation and cancer.
AB - Over the years, interleukin (IL)-27 has received much attention because of its highly divergent, sometimes even opposing, functions in immunity. IL-30, the p28 subunit that forms IL-27 together with Ebi3 and is also known as IL-27p28 or IL-27A, has been considered a surrogate to represent IL-27. However, it was later discovered that IL-30 can form complexes with other protein subunits, potentially leading to overlapping or discrete functions. Furthermore, there is emerging evidence that IL-30 itself may perform immunomodulatory functions independent of Ebi3 or other binding partners and that IL-30 production is strongly associated with certain cancers in humans. In this review, we will discuss the biology of IL-30 and other IL-30-associated cytokines and their functions in inflammation and cancer.
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U2 - 10.1038/s12276-021-00630-x
DO - 10.1038/s12276-021-00630-x
M3 - Review article
C2 - 34045653
AN - SCOPUS:85106704225
VL - 53
SP - 823
EP - 834
JO - Korean Journal of Biochemistry
JF - Korean Journal of Biochemistry
SN - 1226-3613
IS - 5
ER -
