IL-4 and IL-10 inhibition of spontaneous monocyte apoptosis is associated with flip upregulation

Joy Eslick, John C. Scatizzi, Lee Albee, Emily Bickel, Kathleen Bradley, Harris Perlman

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Human peripheral blood monocytes undergo spontaneous apoptosis in culture. Spontaneous monocyte apoptosis is regulated by the death ligand, Fas Ligand (FasL) binding to its receptor Fas. The pro-inflammatory molecules, LPS and IL-1β, prevent spontaneous monocyte apoptosis. Here, we demonstrate that the anti-inflammatory cytokines IL-4 and IL-10 inhibit spontaneous monocyte apoptosis compared to control-treated cells. IL-4- or IL-10-mediated suppression of spontaneous monocyte apoptosis is associated with the induction of Flip, an essential inhibitor of the Fas-death signal. In contrast, IL-4 and IL-10 inhibit LPS or IL-1β induced pro-inflammatory cytokine production. These data suggest that in monocytes IL-4 or IL-10 has a dual function, to inhibit pro-inflammatory cytokine production and to suppress spontaneous apoptosis.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalInflammation
Volume28
Issue number3
DOIs
StatePublished - Jun 1 2004

Keywords

  • Flip
  • anti-inflammatory cytokines
  • apoptosis
  • monocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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