IL-4 inhibits P-glycoprotein in normal and malignant NK cells

Anat R. Tambur; Penelope N. Markham; Howard M. Gebel

doi:10.1016/S0198-8859(98)00042-1

IL-4 inhibits P-glycoprotein in normal and malignant NK cells

Anat R. Tambur, Penelope N. Markham, Howard M. Gebel^*

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at least partially explained by their expression of the multidrug resistant transporter, P-glycoprotein (Pgp). In this study, we demonstrate that the expression and function of Pgp activity on NK cells (leukemic and normal) can be reversed with IL-4.

Original language	English (US)
Pages (from-to)	483-487
Number of pages	5
Journal	Human Immunology
Volume	59
Issue number	8
DOIs	https://doi.org/10.1016/S0198-8859(98)00042-1
State	Published - Aug 1998

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/S0198-8859(98)00042-1

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title = "IL-4 inhibits P-glycoprotein in normal and malignant NK cells",

abstract = "Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at least partially explained by their expression of the multidrug resistant transporter, P-glycoprotein (Pgp). In this study, we demonstrate that the expression and function of Pgp activity on NK cells (leukemic and normal) can be reversed with IL-4.",

author = "Tambur, {Anat R.} and Markham, {Penelope N.} and Gebel, {Howard M.}",

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AU - Tambur, Anat R.

AU - Markham, Penelope N.

AU - Gebel, Howard M.

PY - 1998/8

Y1 - 1998/8

N2 - Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at least partially explained by their expression of the multidrug resistant transporter, P-glycoprotein (Pgp). In this study, we demonstrate that the expression and function of Pgp activity on NK cells (leukemic and normal) can be reversed with IL-4.

AB - Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at least partially explained by their expression of the multidrug resistant transporter, P-glycoprotein (Pgp). In this study, we demonstrate that the expression and function of Pgp activity on NK cells (leukemic and normal) can be reversed with IL-4.

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JF - Human Immunology

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ER -

IL-4 inhibits P-glycoprotein in normal and malignant NK cells

Abstract

ASJC Scopus subject areas

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