IL-4 inhibits P-glycoprotein in normal and malignant NK cells

Anat R. Tambur, Penelope N. Markham, Howard M. Gebel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Patients presenting with a natural killer (NK) cell leukemia generally have a poor prognosis. NK cell tumors are generally resistant to numerous chemotherapeutic drugs and even combination chemotherapy usually results in only short term remissions. The drug resistance of NK cell leukemias may be at least partially explained by their expression of the multidrug resistant transporter, P-glycoprotein (Pgp). In this study, we demonstrate that the expression and function of Pgp activity on NK cells (leukemic and normal) can be reversed with IL-4.

Original languageEnglish (US)
Pages (from-to)483-487
Number of pages5
JournalHuman Immunology
Volume59
Issue number8
DOIs
StatePublished - Aug 1 1998

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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