IL-5 production and CD30 expression in patients with partial IgA deficiency

K. A. Barsness*, R. B. Raby, S. R. Hutchinson, W. R. Valenski, H. G. Herrod

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Partial IgA deficiency (pIgAd) is found in a relatively high proportion of children with recurrent infections. CD30 positive cells and IL-5 have been shown to be important in regulating the production of IgA. We designed a study to look at CD30 expression and IL-5 production in a group of children with pIgAd and age matched controls. pIgAd was defined as IgA levels that are more than 2 standard deviations below the mean for age, but greater than 5 mg/dl. The significance of pIgAd has not been well delineated. We compared the mean results for each group using the unpaired t-test. Expression of phenotypes by stimulated lymphocytes were determined by flow cytometry using commercially available antibodies. IL-5 production was measured by ELISA using a commercially available kit. The following table reflects our results. PATIENTS CONTROLS P VALUE AGE(months) 110.3 127.6 0.2587 SERUM IgA 61.7 mg/dl 171.4 m/dl <0.0001 in vitro IL-5 192.6 pg/ml 294.0 pg/ml 0.2509 CD4+CD30+ 4.0% 2.4 % 0.2277 CD45RO+CD30+ 3.5 % 2.4 % 0.4038 These data indicate pIgAd is unlikely to be secondary to a deficiency in CD30+ cells or in IL-5 production. Further evaluation of the basis of pIgAd may provide insights that could lead to new approaches for managing children with recurrent respiratory tract infections.

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume44
Issue number1
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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