ILDR2-Fc is a novel regulator of immune homeostasis and inducer of antigen-specific immune tolerance

Joseph R. Podojil, Iris Hecht, Ming Yi Chiang, Ilan Vaknin, Inbal Barbiro, Amit Novik, Eyal Neria, Galit Rotman, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

ILDR2 is a member of the Ig superfamily, which is implicated in tricellular tight junctions, and has a putative role in pancreatic islet health and survival. We recently found a novel role for ILDR2 in delivering inhibitory signals to T cells. In this article, we show that short-term treatment with ILDR2-Fc results in long-term durable beneficial effects in the relapsing-remitting experimental autoimmune encephalomyelitis and NOD type 1 diabetes models. ILDR2-Fc also promotes transplant engraftment in a minor mismatch bone marrow transplantation model. ILDR2-Fc displays a unique mode of action, combining immunomodulation, regulation of immune homeostasis, and re-establishment of Ag-specific immune tolerance via regulatory T cell induction. These findings support the potential of ILDR-Fc to provide a promising therapeutic approach for the treatment of autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)2013-2024
Number of pages12
JournalJournal of Immunology
Volume200
Issue number6
DOIs
StatePublished - Mar 15 2018

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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