Abstract
Multifunctional nanoparticles with superior imaging properties and therapeutic effects have been extensively developed for the nanomedicine. However, tumor-intrinsic barriers and tumor heterogeneity have resulted in low in vivo therapeutic efficacy. The poor in vivo targeting efficiency in passive and active targeting of nano-therapeutics along with the toxicity of nanoparticles has been a major problem in nanomedicine. Recently, image-guided nanomedicine, which can deliver nanoparticles locally using non-invasive imaging and interventional oncology techniques, has been paid attention as a new opportunity of nanomedicine. This short review will discuss the existing challenges in nanomedicine and describe the prospects for future image-guided nanomedicine.
| Original language | English (US) |
|---|---|
| Article number | 18 |
| Journal | Journal of Imaging |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2018 |
Funding
This work was supported by grants of R21CA173491, R21CA185274 and R21EB017986 from the National Cancer Institute and National Institute of Biomedical Imaging and Bioengineering.
Keywords
- Cancer
- Image
- Image-guided nanomedicine
- Nanomedicine
- Nanoparticles
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Radiology Nuclear Medicine and imaging
- Computer Vision and Pattern Recognition
- Computer Graphics and Computer-Aided Design
