Image-guided dendritic cell-based vaccine immunotherapy in murine carcinoma models

Bin Wang, Chong Sun, Sijia Wang, Na Shang, Matteo Figini, Quanhong Ma, Shanzhi Gu, Daniele Procissi, Vahid Yaghmai, Guoxin Li*, Andrew Larson, Zhuoli Zhang

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

In recent decades, immunotherapy has undergone extensive developments for oncologic therapy applications. Dendritic cells (DCs) plays a fundamental role in cell-based vaccination immunotherapy against various types of cancer. It involves stimulating innate and adaptive immunity, in particular cytotoxic T-cell mediated antitumor effects, against targeted tumors and has been studied in both preclinical and clinical settings. Nevertheless, clinical outcomes have been unsatisfying. The antitumor response requires sufficient migration of viable DCs from primary administration site to targeted tumors through related lymphatics. The dynamics and mechanisms of the DCs migration still need further investigation. Here, we briefly introduce the current clinically applicable methods for manufacturing DC-based cancer vaccines and their most commonly used non-invasive, real-time tracking approaches. Furthermore, we propose a hypothesis that intraperitoneal injection may improve the efficiency of DC-based cancer vaccine.

Original languageEnglish (US)
Article numberAJTR0057265
Pages (from-to)4564-4573
Number of pages10
JournalAmerican Journal of Translational Research
Volume9
Issue number10
StatePublished - 2017

Keywords

  • Animal models
  • Cancer vaccine
  • Dendritic cells
  • Image techniques

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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  • Cite this

    Wang, B., Sun, C., Wang, S., Shang, N., Figini, M., Ma, Q., Gu, S., Procissi, D., Yaghmai, V., Li, G., Larson, A., & Zhang, Z. (2017). Image-guided dendritic cell-based vaccine immunotherapy in murine carcinoma models. American Journal of Translational Research, 9(10), 4564-4573. [AJTR0057265].