Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Hiroaki Kurihara, David J. Yang*, Massimo Cristofanilli, William D. Erwin, Dong Fang Yu, Saady Kohanim, Richard Mendez, E. Edmund Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use 99mTc EC-annexin V to image tumor cells undergoing apoptosis. Methods: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering 99mTc EC-annexin V. Results: Nine of the 10 cases showed detectable 99mTc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. Conclusions: Apoptosis can be quantified using 99mTc EC-annexin V.

Original languageEnglish (US)
Pages (from-to)1175-1182
Number of pages8
JournalApplied Radiation and Isotopes
Volume66
Issue number9
DOIs
StatePublished - Sep 1 2008

Keywords

  • Annexin V
  • Apoptosis
  • Breast cancer
  • Tc

ASJC Scopus subject areas

  • Radiation

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