Imaging assessment of hepatocellular carcinoma response to locoregional and systemic therapy

Vahid Yaghmai, Cecilia Besa, Edward Kim, Joseph L. Gatlin, Nasir A. Siddiqui, Bachir Taouli*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


OBJECTIVE. This article focuses on imaging techniques and imaging findings after locoregional and systemic therapy in patients with hepatocellular carcinoma (HCC). We discuss currently available locoregional and systemic therapies for HCC, imaging modalities and protocols used to assess HCC response, criteria for assessing HCC response, imaging appearances of treated HCC, and future directions. CONCLUSION. The evaluation of tumor response after systemic and locoregional therapies is essential in directing management for HCC. An understanding of the various therapeutic strategies and of their posttherapy imaging appearances is essential for accurately assessing treatment response. The evaluation of tumor response should include not only anatomic imaging biomarkers, such as reduction in tumor size, but also tumor enhancement and necrosis.

Original languageEnglish (US)
Pages (from-to)80-96
Number of pages17
JournalAmerican Journal of Roentgenology
Issue number1
StatePublished - Jul 2013


  • Ablation
  • CT
  • Hepatocellular carcinoma
  • MRI
  • Transarterial chemoembolization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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