Abstract
Selective internal radiation therapy (SIRT) with 90yttrium microspheres - also known as radioembolisation - is a relatively new interventional radiology technique offering symptomatic and survival advantages for patients with unresectable liver cancer. However, in delivering both beta-particle brachytherapy and embolisation of tumour vasculature, SIRT produces biological sequelae and imaging characteristics distinct from other treatment modalities. Current CT interpretation criteria consistently under-report pathological responses to radioembolisation, diminishing both the prognosis and subsequent treatment choices for responding patients. However, newer criteria incorporating both tumour dimensions and enhancement characteristics improve the correlation with histopathology and provide substantially earlier confirmation of response. CT following radioembolisation may also identify parenchymal features that are often benign but may be mistaken for tumour progression. This review outlines imaging criteria specific to SIRT, including assessment of tumour response and interpretation of both lesion and parenchymal characteristics. The adjunctive role of additional modalities such as positron emission tomography is also addressed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 111-118 |
| Number of pages | 8 |
| Journal | Journal of Medical Imaging and Radiation Oncology |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2011 |
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Keywords
- diagnostic imaging
- interventional radiology
- liver neoplasm
- microsphere
- yttrium radioisotope
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Oncology
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Imaging characteristics following 90yttrium microsphere treatment for unresectable liver cancer. / Bester, Lourens; Hobbins, Peter G.; Wang, Shih Chang; Salem, Riad.
In: Journal of Medical Imaging and Radiation Oncology, Vol. 55, No. 2, 01.04.2011, p. 111-118.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Imaging characteristics following 90yttrium microsphere treatment for unresectable liver cancer
AU - Bester, Lourens
AU - Hobbins, Peter G.
AU - Wang, Shih Chang
AU - Salem, Riad
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Selective internal radiation therapy (SIRT) with 90yttrium microspheres - also known as radioembolisation - is a relatively new interventional radiology technique offering symptomatic and survival advantages for patients with unresectable liver cancer. However, in delivering both beta-particle brachytherapy and embolisation of tumour vasculature, SIRT produces biological sequelae and imaging characteristics distinct from other treatment modalities. Current CT interpretation criteria consistently under-report pathological responses to radioembolisation, diminishing both the prognosis and subsequent treatment choices for responding patients. However, newer criteria incorporating both tumour dimensions and enhancement characteristics improve the correlation with histopathology and provide substantially earlier confirmation of response. CT following radioembolisation may also identify parenchymal features that are often benign but may be mistaken for tumour progression. This review outlines imaging criteria specific to SIRT, including assessment of tumour response and interpretation of both lesion and parenchymal characteristics. The adjunctive role of additional modalities such as positron emission tomography is also addressed.
AB - Selective internal radiation therapy (SIRT) with 90yttrium microspheres - also known as radioembolisation - is a relatively new interventional radiology technique offering symptomatic and survival advantages for patients with unresectable liver cancer. However, in delivering both beta-particle brachytherapy and embolisation of tumour vasculature, SIRT produces biological sequelae and imaging characteristics distinct from other treatment modalities. Current CT interpretation criteria consistently under-report pathological responses to radioembolisation, diminishing both the prognosis and subsequent treatment choices for responding patients. However, newer criteria incorporating both tumour dimensions and enhancement characteristics improve the correlation with histopathology and provide substantially earlier confirmation of response. CT following radioembolisation may also identify parenchymal features that are often benign but may be mistaken for tumour progression. This review outlines imaging criteria specific to SIRT, including assessment of tumour response and interpretation of both lesion and parenchymal characteristics. The adjunctive role of additional modalities such as positron emission tomography is also addressed.
KW - diagnostic imaging
KW - interventional radiology
KW - liver neoplasm
KW - microsphere
KW - yttrium radioisotope
UR - http://www.scopus.com/inward/record.url?scp=79955066061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955066061&partnerID=8YFLogxK
U2 - 10.1111/j.1754-9485.2011.02241.x
DO - 10.1111/j.1754-9485.2011.02241.x
M3 - Review article
C2 - 21501398
AN - SCOPUS:79955066061
VL - 55
SP - 111
EP - 118
JO - Journal of Medical Imaging and Radiation Oncology
JF - Journal of Medical Imaging and Radiation Oncology
SN - 1754-9477
IS - 2
ER -