Imaging characteristics following 90yttrium microsphere treatment for unresectable liver cancer

Lourens Bester*, Peter G. Hobbins, Shih Chang Wang, Riad Salem

*Corresponding author for this work

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Selective internal radiation therapy (SIRT) with 90yttrium microspheres - also known as radioembolisation - is a relatively new interventional radiology technique offering symptomatic and survival advantages for patients with unresectable liver cancer. However, in delivering both beta-particle brachytherapy and embolisation of tumour vasculature, SIRT produces biological sequelae and imaging characteristics distinct from other treatment modalities. Current CT interpretation criteria consistently under-report pathological responses to radioembolisation, diminishing both the prognosis and subsequent treatment choices for responding patients. However, newer criteria incorporating both tumour dimensions and enhancement characteristics improve the correlation with histopathology and provide substantially earlier confirmation of response. CT following radioembolisation may also identify parenchymal features that are often benign but may be mistaken for tumour progression. This review outlines imaging criteria specific to SIRT, including assessment of tumour response and interpretation of both lesion and parenchymal characteristics. The adjunctive role of additional modalities such as positron emission tomography is also addressed.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalJournal of Medical Imaging and Radiation Oncology
Volume55
Issue number2
DOIs
StatePublished - Apr 1 2011

Fingerprint

Liver Neoplasms
Microspheres
Radiotherapy
Neoplasms
Beta Particles
Interventional Radiology
Brachytherapy
Therapeutics
Positron-Emission Tomography
Survival

Keywords

  • diagnostic imaging
  • interventional radiology
  • liver neoplasm
  • microsphere
  • yttrium radioisotope

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

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title = "Imaging characteristics following 90yttrium microsphere treatment for unresectable liver cancer",
abstract = "Selective internal radiation therapy (SIRT) with 90yttrium microspheres - also known as radioembolisation - is a relatively new interventional radiology technique offering symptomatic and survival advantages for patients with unresectable liver cancer. However, in delivering both beta-particle brachytherapy and embolisation of tumour vasculature, SIRT produces biological sequelae and imaging characteristics distinct from other treatment modalities. Current CT interpretation criteria consistently under-report pathological responses to radioembolisation, diminishing both the prognosis and subsequent treatment choices for responding patients. However, newer criteria incorporating both tumour dimensions and enhancement characteristics improve the correlation with histopathology and provide substantially earlier confirmation of response. CT following radioembolisation may also identify parenchymal features that are often benign but may be mistaken for tumour progression. This review outlines imaging criteria specific to SIRT, including assessment of tumour response and interpretation of both lesion and parenchymal characteristics. The adjunctive role of additional modalities such as positron emission tomography is also addressed.",
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Imaging characteristics following 90yttrium microsphere treatment for unresectable liver cancer. / Bester, Lourens; Hobbins, Peter G.; Wang, Shih Chang; Salem, Riad.

In: Journal of Medical Imaging and Radiation Oncology, Vol. 55, No. 2, 01.04.2011, p. 111-118.

Research output: Contribution to journalReview article

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AU - Hobbins, Peter G.

AU - Wang, Shih Chang

AU - Salem, Riad

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