Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography

Qi Liu, Siyu Chen, Brian Soetikno, Shanbao Tong, Hao F. Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Monitoring hemodynamic responses in the rodent stroke model is important in the study of ischemic stroke. However, it is hard for a single imaging modality to comprehensively explore these changes. In this study, we implemented laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to detect cerebral blood flow (CBF), angiography and oxygen saturation (sO2) in the mouse model of distal middle cerebral artery occlusion (dMCAO). LSI provides full-field, real-time cerebral blood flow (CBF) map to guide the Vis-OCT imaging. Vis-OCT offers angiography and sO2 measurements. The results showed the detailed CBF and vasculature changes before and after dMCAO. After dMCAO, sO2 changed little in arteries and arterioles, while sO2 decreased in veins and venules. We also showed that larger veins had a higher decrease in sO2 value in consecutive vein branches after dMCAO. It is suggested that the combination of LSI/Vis-OCT provides a promising tool for the rodent stroke model study.

Original languageEnglish (US)
Title of host publication8th International IEEE EMBS Conference on Neural Engineering, NER 2017
PublisherIEEE Computer Society
Pages62-65
Number of pages4
ISBN (Electronic)9781538619162
DOIs
StatePublished - Aug 10 2017
Event8th International IEEE EMBS Conference on Neural Engineering, NER 2017 - Shanghai, China
Duration: May 25 2017May 28 2017

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other8th International IEEE EMBS Conference on Neural Engineering, NER 2017
Country/TerritoryChina
CityShanghai
Period5/25/175/28/17

ASJC Scopus subject areas

  • Artificial Intelligence
  • Mechanical Engineering

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