Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography

Qi Liu; Siyu Chen; Brian Soetikno; Shanbao Tong; Hao F. Zhang

doi:10.1109/NER.2017.8008292

Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography

Qi Liu, Siyu Chen, Brian Soetikno, Shanbao Tong, Hao F. Zhang

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Monitoring hemodynamic responses in the rodent stroke model is important in the study of ischemic stroke. However, it is hard for a single imaging modality to comprehensively explore these changes. In this study, we implemented laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to detect cerebral blood flow (CBF), angiography and oxygen saturation (sO₂) in the mouse model of distal middle cerebral artery occlusion (dMCAO). LSI provides full-field, real-time cerebral blood flow (CBF) map to guide the Vis-OCT imaging. Vis-OCT offers angiography and sO₂ measurements. The results showed the detailed CBF and vasculature changes before and after dMCAO. After dMCAO, sO₂ changed little in arteries and arterioles, while sO₂ decreased in veins and venules. We also showed that larger veins had a higher decrease in sO₂ value in consecutive vein branches after dMCAO. It is suggested that the combination of LSI/Vis-OCT provides a promising tool for the rodent stroke model study.

Original language	English (US)
Title of host publication	8th International IEEE EMBS Conference on Neural Engineering, NER 2017
Publisher	IEEE Computer Society
Pages	62-65
Number of pages	4
ISBN (Electronic)	9781538619162
DOIs	https://doi.org/10.1109/NER.2017.8008292
State	Published - Aug 10 2017
Event	8th International IEEE EMBS Conference on Neural Engineering, NER 2017 - Shanghai, China Duration: May 25 2017 → May 28 2017

Publication series

Name	International IEEE/EMBS Conference on Neural Engineering, NER
ISSN (Print)	1948-3546
ISSN (Electronic)	1948-3554

Other

Other	8th International IEEE EMBS Conference on Neural Engineering, NER 2017
Country/Territory	China
City	Shanghai
Period	5/25/17 → 5/28/17

Funding

*Resrach supported by the NIH grants R24EY022883, DP3DK108248, R01EY026078; NSF grants CBET-1055379, DBI-1353952; Chinese program of introducing talents to Universities (111 Project, No. B08020); Q. L. is also supported by the China Scholarship Council (201406230188); S. T. is also supported by the NSFC grant (No. 61371018).

ASJC Scopus subject areas

Artificial Intelligence
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/NER.2017.8008292

Cite this

Liu, Q., Chen, S., Soetikno, B., Tong, S., & Zhang, H. F. (2017). Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography. In 8th International IEEE EMBS Conference on Neural Engineering, NER 2017 (pp. 62-65). Article 8008292 (International IEEE/EMBS Conference on Neural Engineering, NER). IEEE Computer Society. https://doi.org/10.1109/NER.2017.8008292

Liu, Qi ; Chen, Siyu ; Soetikno, Brian et al. / Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography. 8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society, 2017. pp. 62-65 (International IEEE/EMBS Conference on Neural Engineering, NER).

@inproceedings{4021d49ac58b47c0b4d9261039576047,

title = "Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography",

abstract = "Monitoring hemodynamic responses in the rodent stroke model is important in the study of ischemic stroke. However, it is hard for a single imaging modality to comprehensively explore these changes. In this study, we implemented laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to detect cerebral blood flow (CBF), angiography and oxygen saturation (sO2) in the mouse model of distal middle cerebral artery occlusion (dMCAO). LSI provides full-field, real-time cerebral blood flow (CBF) map to guide the Vis-OCT imaging. Vis-OCT offers angiography and sO2 measurements. The results showed the detailed CBF and vasculature changes before and after dMCAO. After dMCAO, sO2 changed little in arteries and arterioles, while sO2 decreased in veins and venules. We also showed that larger veins had a higher decrease in sO2 value in consecutive vein branches after dMCAO. It is suggested that the combination of LSI/Vis-OCT provides a promising tool for the rodent stroke model study.",

author = "Qi Liu and Siyu Chen and Brian Soetikno and Shanbao Tong and Zhang, {Hao F.}",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 8th International IEEE EMBS Conference on Neural Engineering, NER 2017 ; Conference date: 25-05-2017 Through 28-05-2017",

year = "2017",

month = aug,

day = "10",

doi = "10.1109/NER.2017.8008292",

language = "English (US)",

series = "International IEEE/EMBS Conference on Neural Engineering, NER",

publisher = "IEEE Computer Society",

pages = "62--65",

booktitle = "8th International IEEE EMBS Conference on Neural Engineering, NER 2017",

address = "United States",

}

Liu, Q, Chen, S, Soetikno, B, Tong, S & Zhang, HF 2017, Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography. in 8th International IEEE EMBS Conference on Neural Engineering, NER 2017., 8008292, International IEEE/EMBS Conference on Neural Engineering, NER, IEEE Computer Society, pp. 62-65, 8th International IEEE EMBS Conference on Neural Engineering, NER 2017, Shanghai, China, 5/25/17. https://doi.org/10.1109/NER.2017.8008292

Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography. / Liu, Qi; Chen, Siyu; Soetikno, Brian et al.
8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society, 2017. p. 62-65 8008292 (International IEEE/EMBS Conference on Neural Engineering, NER).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography

AU - Liu, Qi

AU - Chen, Siyu

AU - Soetikno, Brian

AU - Tong, Shanbao

AU - Zhang, Hao F.

PY - 2017/8/10

Y1 - 2017/8/10

N2 - Monitoring hemodynamic responses in the rodent stroke model is important in the study of ischemic stroke. However, it is hard for a single imaging modality to comprehensively explore these changes. In this study, we implemented laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to detect cerebral blood flow (CBF), angiography and oxygen saturation (sO2) in the mouse model of distal middle cerebral artery occlusion (dMCAO). LSI provides full-field, real-time cerebral blood flow (CBF) map to guide the Vis-OCT imaging. Vis-OCT offers angiography and sO2 measurements. The results showed the detailed CBF and vasculature changes before and after dMCAO. After dMCAO, sO2 changed little in arteries and arterioles, while sO2 decreased in veins and venules. We also showed that larger veins had a higher decrease in sO2 value in consecutive vein branches after dMCAO. It is suggested that the combination of LSI/Vis-OCT provides a promising tool for the rodent stroke model study.

AB - Monitoring hemodynamic responses in the rodent stroke model is important in the study of ischemic stroke. However, it is hard for a single imaging modality to comprehensively explore these changes. In this study, we implemented laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to detect cerebral blood flow (CBF), angiography and oxygen saturation (sO2) in the mouse model of distal middle cerebral artery occlusion (dMCAO). LSI provides full-field, real-time cerebral blood flow (CBF) map to guide the Vis-OCT imaging. Vis-OCT offers angiography and sO2 measurements. The results showed the detailed CBF and vasculature changes before and after dMCAO. After dMCAO, sO2 changed little in arteries and arterioles, while sO2 decreased in veins and venules. We also showed that larger veins had a higher decrease in sO2 value in consecutive vein branches after dMCAO. It is suggested that the combination of LSI/Vis-OCT provides a promising tool for the rodent stroke model study.

UR - http://www.scopus.com/inward/record.url?scp=85028598294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028598294&partnerID=8YFLogxK

U2 - 10.1109/NER.2017.8008292

DO - 10.1109/NER.2017.8008292

M3 - Conference contribution

AN - SCOPUS:85028598294

T3 - International IEEE/EMBS Conference on Neural Engineering, NER

SP - 62

EP - 65

BT - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017

PB - IEEE Computer Society

T2 - 8th International IEEE EMBS Conference on Neural Engineering, NER 2017

Y2 - 25 May 2017 through 28 May 2017

ER -

Liu Q, Chen S, Soetikno B, Tong S, Zhang HF. Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography. In 8th International IEEE EMBS Conference on Neural Engineering, NER 2017. IEEE Computer Society. 2017. p. 62-65. 8008292. (International IEEE/EMBS Conference on Neural Engineering, NER). doi: 10.1109/NER.2017.8008292

Imaging hemodynamic response after distal middle cerebral artery occlusion with combined laser speckle imaging and visible-light optical coherence tomography

Abstract

Publication series

Other

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this