Imaging nanoparticles in cells by nanomechanical holography

Laurene Tetard, Ali Passian*, Katherine T. Venmar, Rachel M. Lynch, Brynn H. Voy, Gajendra Shekhawat, Vinayak P. Dravid, Thomas Thundat

*Corresponding author for this work

Research output: Contribution to journalArticle

123 Scopus citations


Nanomaterials have potential medical applications, for example in the area of drug delivery, and their possible adverse effects and cytotoxicity are curently receiving attention. Inhalation of nanoparticles is of great concern, because nanoparticles can be easily aerosolized. Imaging techniques that can visualize local populations of nanoparticles at nanometre resolution within the structures of cells are therefore important. Here we show that cells obtained from mice exposed to single-walled carbon nanohorns can be probed using a scanning probe microscopy technique called scanning near field ultrasonic holography. The nanohorns were observed inside the cells, and this was further confirmed using micro Raman spectroscopy. Scanning near field ultrasonic holography is a useful technique for probing the interactions of engineered nanomaterials in biological systems, which will greatly benefit areas in drug delivery and nanotoxicology.

Original languageEnglish (US)
Pages (from-to)501-505
Number of pages5
JournalNature nanotechnology
Issue number8
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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  • Cite this

    Tetard, L., Passian, A., Venmar, K. T., Lynch, R. M., Voy, B. H., Shekhawat, G., Dravid, V. P., & Thundat, T. (2008). Imaging nanoparticles in cells by nanomechanical holography. Nature nanotechnology, 3(8), 501-505.